Nature Cell BiologyIF 22.7

Acidic niche sugar shield blocks ferroptosis

Mario Palma & Jessalyn M. Ubellacker

Mar 2026

1,736views

Glioblastoma diagram comparing neutral pH and chronic acidosis, glycocalyx changes, and suppressed ferroptosis

Turn your ideas, research, and data into scientific illustrations, flowcharts, and plots with AI.

Abstract

Tumour acidosis is known to drive metabolic adaptations in cancer cells, contributing to their survival and resistance to therapies. A study now identifies a chondroitin sulfate-enriched glycocalyx as a key feature of the acidic tumour microenvironment in glioblastoma that limits lipid uptake and protects cells against death by ferroptosis.

Create scientific figures with FigureLabs.

Abstract