Cell ResearchIF 31.1

MitoCatch directs mitochondria delivery and prevents cell degeneration

Ana Paula Mendonça & Luca Scorrano

2026年6月

968次浏览

MitoCatch system delivering mitochondria into retinal ganglion cells in a mouse eye to prevent neurodegeneration

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摘要

Mitochondrial transplantation is a promising therapeutic strategy to restore cellular metabolism and prevent cell death once limitations like delivery efficiency, organelle viability post-isolation, and cell-type specificity are surpassed. In this issue of Nature, Ayupov et al. introduce MitoCatch, a targeted transplantation system showing selective organelle internalization, offering precision for disease treatment.

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摘要