Nature Cell BiologyIF 22.7

Acidic niche sugar shield blocks ferroptosis

Mario Palma & Jessalyn M. Ubellacker

2026年3月

1,736次浏览

Glioblastoma diagram comparing neutral pH and chronic acidosis, glycocalyx changes, and suppressed ferroptosis

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摘要

Tumour acidosis is known to drive metabolic adaptations in cancer cells, contributing to their survival and resistance to therapies. A study now identifies a chondroitin sulfate-enriched glycocalyx as a key feature of the acidic tumour microenvironment in glioblastoma that limits lipid uptake and protects cells against death by ferroptosis.

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摘要